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Beyond ALT Text: Making the Web Easy to Use for Users with Disabilities  (Research based)

On this website, one can find a 2001 pdf document, with design guidelines for websites based on usability studies with people using assistive technology. The author qualifies (post 2001) that progress with assistive technology for blind readers has been slow, and "that some of the specific technical comments in this report may not apply to recent versions of the products discussed".

Nielsen Norman Group

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New information and communications technologies can improve the quality of life for people with disabilities, but only if such technologies are designed from the beginning so that everyone can use them. Given the explosive growth in the use of the World Wide Web for publishing, electronic commerce, lifelong learning and the delivery of government services, it is vital that the Web be accessible to everyone.

Bill Clinton